diff --git a/trytond/tests/test_tools.py b/trytond/tests/test_tools.py
index 58a32a89f7..8fd1433ad1 100644
--- a/trytond/tests/test_tools.py
+++ b/trytond/tests/test_tools.py
@@ -540,6 +540,11 @@ class DomainInversionTestCase(unittest.TestCase):
         self.assertTrue(eval_domain(domain, {'x': [3]}))
         self.assertTrue(eval_domain(domain, {'x': [3, 4]}))
         self.assertFalse(eval_domain(domain, {'x': [1, 2]}))
+        self.assertFalse(eval_domain(domain, {'x': None}))
+
+        domain = [['x', 'in', [1, None]]]
+        self.assertTrue(eval_domain(domain, {'x': None}))
+        self.assertFalse(eval_domain(domain, {'x': 2}))
 
         domain = [['x', 'not in', [3, 5]]]
         self.assertFalse(eval_domain(domain, {'x': 3}))
@@ -547,6 +552,11 @@ class DomainInversionTestCase(unittest.TestCase):
         self.assertFalse(eval_domain(domain, {'x': [3]}))
         self.assertFalse(eval_domain(domain, {'x': [3, 4]}))
         self.assertTrue(eval_domain(domain, {'x': [1, 2]}))
+        self.assertFalse(eval_domain(domain, {'x': None}))
+
+        domain = [['x', 'not in', [1, None]]]
+        self.assertFalse(eval_domain(domain, {'x': None}))
+        self.assertTrue(eval_domain(domain, {'x': 2}))
 
         domain = [['x', 'like', 'abc']]
         self.assertTrue(eval_domain(domain, {'x': 'abc'}))
diff --git a/trytond/tools/domain_inversion.py b/trytond/tools/domain_inversion.py
index 9c88530496..f68662eaee 100644
--- a/trytond/tools/domain_inversion.py
+++ b/trytond/tools/domain_inversion.py
@@ -96,7 +96,10 @@ def eval_leaf(part, context, boolop=operator.and_):
         return bool(context.get(field.split('.')[0]))
     context_field = context.get(field)
     if (operand not in {'=', '!='}
-            and (context_field is None or value is None)):
+            and (context_field is None or value is None)
+            and not (operand in {'in', 'not in'}
+                and context_field is None
+                and (isinstance(value, (list, tuple)) and None in value))):
         return
     if isinstance(context_field, datetime.date) and not value:
         if isinstance(context_field, datetime.datetime):